This 2015 case-control study investigated the association between blood cadmium levels (BCLs) and breast cancer risk among 186 female patients and 139 controls in the Chaoshan region of southeast China. Breast cancer patients exhibited significantly higher median BCLs (2.28 μg/L) compared to controls (1.77 μg/L; P = 0.001). The proportion
A study examined the effects of Provera, a progestational compound, on the efficacy of chemotherapy in various uterine cancer cell lines. Using the ATP chemosensitivity assay and flow cytometry, researchers analyzed progesterone-receptor (PR)-positive (AE7 and ECC1) and PR-negative (HEC1A, HEC1B, AN3, and SKUT1B) cell lines. The findings showed that Provera
This study investigates the effects of sulindac sulfide and exisulind on hormone receptor signaling in breast cancer cells. Both compounds were found to inhibit the expression of estrogen and progesterone receptors in estrogen receptor-positive (ER-positive) T47D cells, leading to growth inhibition. They also reduced estrogen-stimulated activation of estrogen-responsive promoters. The
