This 2012 review article discusses the application of autologous platelet-rich fibrin matrix (PRFM) in facial plastic surgery. PRFM is utilized for volume augmentation, fat transfer supplementation, and as an adjunct to open surgical procedures. The article highlights PRFM’s role in enhancing wound healing and tissue regeneration due to its sustained
This 2024 critical review evaluates the efficacy of platelet-based therapies—such as platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM)—in facial rejuvenation and wound healing. The authors analyze various studies, highlighting the potential benefits of these treatments in promoting tissue regeneration and aesthetic improvement. However, they also emphasize the need for
This clinical trial assessed the histological effects of autologous platelet-rich fibrin matrix (PRFM) injections in human skin. Four healthy adult volunteers received PRFM injections into the deep dermis and subdermis of the upper arms. Biopsies over a 10-week period revealed early fibroblast activation and collagen deposition by day 7, angiogenesis
This 2010 study evaluated the efficacy of a single injection of autologous platelet-rich fibrin matrix (PRFM) for correcting deep nasolabial folds (NLFs). Fifteen adults received PRFM injections prepared using the Selphyl system. Assessments using the Wrinkle Assessment Scale (WAS) and Global Aesthetic Improvement Scale showed significant improvements: mean WAS scores
