This 2024 Cochrane systematic review assessed the efficacy and safety of zinc supplementation in preventing and treating the common cold. The analysis included 31 randomized controlled trials with over 2,400 participants. Findings indicated that zinc supplementation may have little or no effect on preventing colds (RR 0.93; 95% CI 0.85–1.01;
This 2021 comprehensive review article provides an in-depth analysis of Lyme disease, a tick-borne illness caused by Borrelia burgdorferi sensu lato complex. The disease is prevalent across the Northern Hemisphere and is transmitted by ticks from the Ixodes ricinus complex. The article discusses the increasing global incidence of Lyme disease,
This Cochrane systematic review analyzed 29 randomized trials to assess the efficacy of vitamin C in preventing and treating the common cold. The findings indicated that regular vitamin C supplementation (≥200 mg/day) did not significantly reduce the incidence of colds in the general population. However, among individuals exposed to extreme
This large-scale, randomized, double-blind, placebo-controlled trial investigated whether daily supplementation with vitamin D₃ (2000 IU) and/or marine omega-3 fatty acids (1000 mg) reduces the incidence of autoimmune diseases. Over a median follow-up of 5.3 years among 25,871 U.S. adults aged ≥50 (men) and ≥55 (women), vitamin D supplementation led to
This article proposes that thiamine (vitamin B1) supplementation may serve as a preventive strategy against Alzheimer’s disease (AD) in elderly individuals who are cognitively normal but exhibit amyloid or tau deposition. Thiamine deficiency is common in older adults and is associated with several AD-related pathologies, including synaptic hypometabolism, mitochondrial dysfunction,
This review highlights the potential of nutraceuticals—bioactive compounds derived from food sources—in preventing Alzheimer’s disease (AD). The authors discuss how certain nutraceuticals, such as quercetin, biocurcumin, rosmarinic acid, Andean shilajit, anthocyanidins, and hydroxytyrosol, exhibit antioxidant, anti-inflammatory, and anti-amyloid properties. These compounds may interfere with AD pathogenesis by reducing oxidative stress,
This comprehensive review highlights a significant global increase in early-onset cancers (diagnosed before age 50), including breast, colorectal, endometrial, and pancreatic cancers. While improved screening contributes to some cases, a genuine rise is attributed to early-life exposures such as dietary changes, obesity, sedentary lifestyles, environmental toxins, and microbiome alterations. The
This review discusses emerging evidence supporting the role of testosterone (T), alone or in combination with the aromatase inhibitor anastrozole (T+A), in reducing the incidence of breast cancer and possibly treating existing hormone receptor-positive tumors. Subcutaneous T or T+A implants have demonstrated symptom relief in women with androgen deficiency, including
This observational study investigated dietary patterns and their link to type 2 diabetes (T2D) risk in a cohort of 10,000 adults. It found that adherence to a Mediterranean diet was associated with a 25% reduced risk of T2D (p
This meta-analysis investigates the relationship between coronary artery calcium (CAC) scores and cardiovascular events in individuals without established coronary artery disease (CAD). The study found that higher CAC scores are associated with an increased risk of cardiovascular events (hazard ratio 2.2; 95% CI: 1.6-3.0), suggesting CAC as an important predictor
