The Early versus Late Intervention Trial with Estradiol (ELITE) was a randomized, double-blind, placebo-controlled study that assessed the impact of oral 17β-estradiol (1 mg/day) on subclinical atherosclerosis in 643 healthy postmenopausal women. Participants were stratified into early (
This 2011 prospective cohort study assessed the impact of combined estradiol and testosterone implants on bone mineral density (BMD) in postmenopausal women. Sixty-one participants were divided into two groups: 34 women received hormone implants, while 27 did not undergo hormonal therapy. Over one year, the implant group maintained or slightly
A study published in the Journal of the National Cancer Institute in 2000 (PMID: 10675382) examined the effects of hormone replacement therapy (HRT) on breast cancer risk among postmenopausal women aged 55-72. The analysis of 1,897 breast cancer cases and 1,637 controls found that combined HRT (estrogen plus progestin) increased
The study titled “Depression and the menopause: why antidepressants are not enough?” (Menopause International, 2009, PMID: 19465674) explores the link between menopause and depression, highlighting that postmenopausal depression is often more severe, insidious, and resistant to conventional antidepressants. Key findings suggest that combining hormone therapy (HT) with antidepressants results in
