Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
This 2016 study investigated the metabolic effects of vitamin C on KRAS mutant colorectal cancer (CRC) cells. It found that vitamin C disrupts the Warburg effect by impairing glycolysis through several mechanisms: detachment of RAS from the plasma membrane, inhibition of ERK1/2 signaling, and reduction in PKM2 Ser37 phosphorylation. These
June 26, 2025
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