Well Referenced

Tag: pituitary dysfunction

The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients with longstanding post-irradiation GH insufficiency

This randomized controlled trial (PMID: 10754477) assessed GH secretion responses to low-dose bolus GHRH(1-29)NH2 in 5 adult male survivors of childhood brain tumors post-cranial irradiation (>30 Gy) compared to 5 healthy controls. GH peaks and AUC were significantly lower in irradiated patients at both moderate (4.5 vs 37.4 mU/L, P

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June 26, 2025 No Comments

The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in GH pulse generation: studies in normal and post-cranial irradiated individuals

This randomized controlled trial (PMID: 10594518) evaluated how continuous GHRH(1-29)NH2 infusion and intermittent somatostatin withdrawal influenced GH pulse generation in n=12 long-term survivors and n=6 short-term survivors of childhood brain tumors post-cranial irradiation, compared to n=9 and n=6 healthy matched controls. In healthy adults, pulsatile GH secretion persisted under GHRH

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June 26, 2025 No Comments