Drivers of age-related inflammation and strategies for healthspan extension
This review discusses the role of chronic inflammation driven by the NLRP3 inflammasome in age-related conditions such as arthritis, diabetes, cardiovascular disease, and Alzheimer’s disease. It highlights how the accumulation of damage-associated molecular patterns (DAMPs) with age activates NLRP3, increasing IL-1β and IL-18 production and contributing to systemic inflammation. The
June 26, 2025
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