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Tag: peptide therapy

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

This 2019 preclinical study evaluated the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, on spinal cord injury (SCI) in rats. Following laminectomy and compression injury at the L2–L3 level, rats received a single intraperitoneal injection of BPC 157 (2 or 200 μg/kg) or saline 10 minutes post-injury. BPC

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June 26, 2025 No Comments

Striated, Smooth, and Heart Muscle

This 2022 review article explores the therapeutic potential of the stable gastric pentadecapeptide BPC 157 in the regeneration and functional recovery of striated, smooth, and cardiac muscles. BPC 157 demonstrates cytoprotective properties that facilitate healing in various muscle injuries, including myotendinous junction disruptions, by promoting angiogenesis, fibroblast proliferation, and collagen

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June 26, 2025 No Comments

GH responses to intravenous bolus infusions of GH-releasing hormone and GH-releasing peptide-2 separately and in combination in adult volunteers

This randomized controlled trial evaluated the effects of intravenous administration of growth hormone-releasing hormone (GHRH1-29NH2) and growth hormone-releasing peptide-2 (GHRP-2), individually and combined, on growth hormone (GH) secretion in healthy adult males. GHRP-2 alone significantly increased GH secretion (AUC: 6205.1 ± 3216.9 mU/l·min) compared to GHRH alone (AUC: 2061.2 ±

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June 26, 2025 No Comments

Growth hormone (GH)-releasing effects of synthetic peptide GH-releasing peptide-2 and GH-releasing hormone (1-29)NH2 in children with GH insufficiency and idiopathic short stature

This randomized controlled trial investigated the effects of GHRH1-29NH2 and GHRP-2, both individually and in combination, on growth hormone (GH) release in children with growth hormone insufficiency and idiopathic short stature. The results indicated that while both peptides effectively stimulated GH secretion, the combination of GHRH1-29NH2 and GHRP-2 had a

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June 26, 2025 No Comments

Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy

This review examines the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, on fistula healing in rat models. Originally identified as an anti-ulcer agent, BPC 157 remains stable in human gastric juice for over 24 hours and has shown consistent efficacy in promoting the healing of gastrointestinal fistulas. The

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June 26, 2025 No Comments

Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing

This systematic review examines the potential of BPC 157, a pentadecapeptide, in promoting soft tissue healing, particularly for musculoskeletal injuries such as tendons, ligaments, and muscles. Although research has predominantly been conducted in rodent models, BPC 157 has shown promise in accelerating tissue recovery, especially in hypovascular and hypocellular tissues.

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June 26, 2025 No Comments