Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction
This 2022 randomized, double-blind, placebo-controlled trial evaluated the safety and tolerability of nicotinamide riboside (NR) in 30 patients with clinically stable heart failure with reduced ejection fraction (HFrEF). Participants received escalating doses of NR, reaching 1,000 mg twice daily over 12 weeks. The study found that NR was safe and