Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)
This 2015 review by Islam et al. examines the detrimental effects of peroxynitrite-induced DNA damage and the subsequent activation of poly(ADP-ribose) polymerase (PARP) in various human diseases. Peroxynitrite, formed by the reaction of nitric oxide with superoxide radicals, can cause DNA strand breaks, leading to the overactivation of PARP. This
June 26, 2025
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