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Tag: PARP Inhibitors

Recent Advances in Therapeutic Strategies for Triple-Negative Breast Cancer

This 2022 review comprehensively examines the latest therapeutic developments for triple-negative breast cancer (TNBC), a highly aggressive and heterogeneous subtype lacking hormone receptors and HER2 expression. The article outlines current treatment paradigms including chemotherapy, and highlights advancements such as immune checkpoint inhibitors (e.g., pembrolizumab, atezolizumab) for PD-L1-positive TNBC and PARP

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June 26, 2025 No Comments

Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)

This 2015 review by Islam et al. examines the detrimental effects of peroxynitrite-induced DNA damage and the subsequent activation of poly(ADP-ribose) polymerase (PARP) in various human diseases. Peroxynitrite, formed by the reaction of nitric oxide with superoxide radicals, can cause DNA strand breaks, leading to the overactivation of PARP. This

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June 26, 2025 No Comments