This 2022 review explores the critical role of NAD⁺ in skeletal muscle health, particularly in the contexts of aging and exercise. It outlines how NAD⁺ functions as a coenzyme in metabolic pathways and as a substrate for enzymes like sirtuins (SIRTs), PARP-1, and CD38. The paper discusses how aging and
This review article highlights the critical role of nicotinamide adenine dinucleotide (NAD⁺) deficiency in various diseases and aging processes. It discusses how NAD⁺ deficiency is observed in models of cerebral ischemia, myocardial ischemia, diabetes, and aging. The deficiency results from factors like poly(ADP-ribose) polymerase-1 (PARP-1) activation, decreased nicotinamide phosphoribosyltransferase (Nampt)
This study investigated quercetin’s ability to modulate histamine H1 receptor (H1R) gene expression in HeLa cells and its effects on allergy-like symptoms in TDI-sensitized rats. Quercetin suppressed histamine- and PMA-induced up-regulation of H1R by inhibiting PKC-δ activation and its translocation, reducing allergy-like symptoms in rats. In vivo, it also decreased
