Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment
This 2002 randomized, double-blind study evaluated weight changes over 26–32 weeks in 284 patients with major depressive disorder treated with fluoxetine, sertraline, or paroxetine. Paroxetine-treated patients experienced a significant average weight gain of 3.6%, with 25.5% gaining more than 7% of their baseline weight. In contrast, fluoxetine-treated patients had a
June 26, 2025
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