This 2013 randomized controlled trial evaluated the efficacy of extracorporeal shockwave therapy (ESWT) in 70 patients with knee osteoarthritis (KOA). Participants were randomized to receive either ESWT (n=34; 4000 pulses at 0.25 mJ/mm² weekly for 4 weeks) or placebo (n=36; sham treatment at 0 mJ/mm²). Outcomes were assessed at baseline,
This 2020 systematic review and meta-analysis evaluated the efficacy and safety of extracorporeal shockwave therapy (ESWT) in treating knee osteoarthritis (KOA). Analyzing three randomized controlled trials and three cohort studies encompassing 589 patients, the study found that ESWT significantly reduced pain scores at 4, 8, and 12 weeks post-treatment, with
This 2020 systematic review and meta-analysis evaluated the efficacy and safety of extracorporeal shock wave therapy (ESWT) in treating osteoarthritis (OA). The analysis included randomized controlled trials comparing ESWT with other treatments such as placebo, corticosteroids, hyaluronic acid, medications, ultrasound, kinesiotherapy, moxibustion, acupotomy surgery, platelet-rich plasma, fumigation, and manipulation. ESWT
This Phase I/II randomized controlled trial assessed the safety and efficacy of intra-articular injections of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in patients with symptomatic knee osteoarthritis (OA). Participants were randomized into three groups: hyaluronic acid (HA) injections at baseline and 6 months (n=8), a single UC-MSC dose at baseline
This study evaluated the efficacy of oxygen-ozone autohemotherapy (O2-O3-AHT) for treating fibromyalgia (FM), a chronic condition characterized by pain, fatigue, and musculoskeletal issues. Involving 200 patients, the study demonstrated that 76% of participants experienced significant rehabilitation of musculoskeletal function and reduced arthralgia after 3-4 O2-O3-AHT sessions. Pain scores measured using
This meta-analysis compared platelet-rich plasma (PRP) therapy with other treatments for plantar fasciitis, finding that PRP significantly reduced pain and improved functional outcomes compared to extracorporeal shock wave therapy (ESWT) and corticosteroid injections (CSI). With a pooled sample of 1,356 patients across 21 RCTs, PRP showed a superior effect in
This review explores the mechanisms of photobiomodulation (PBM), a therapy using red or near-infrared light at low power densities to reduce pain, inflammation, and edema while promoting tissue regeneration, including wound healing, bone repair, and tendon recovery. PBM primarily targets cytochrome c oxidase (CCO) in mitochondria, dissociating inhibitory nitric oxide
