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Tag: p53

Re-oxygenation Causes Hypoxic Tumor Regression Through Restoration of p53 Wild-Type Conformation and Post-Translational Modifications

This 2012 study explored how re-oxygenation impacts hypoxic tumors by restoring wild-type functionality to p53, a key tumor suppressor often rendered inactive under low oxygen conditions. Under hypoxia, p53 assumes a mutant-like conformation that diminishes its transcriptional and tumor-suppressive activities. Re-oxygenation with 30% oxygen at normobaric pressure reversed these effects

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June 26, 2025 No Comments

Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells

This 2014 study explores the requirement of nucleostemin (NS), a stem/progenitor cell marker, in mediating the anti-proliferative action of indole-3-carbinol (I3C) in human breast cancer cells, particularly HER2-overexpressing 10AT-Her2 cells. These cells exhibit cancer stem cell-like traits (CD44+/CD24−/low and high ALDH-1 activity). Treatment with I3C significantly inhibited tumorsphere formation and

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June 26, 2025 No Comments

Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways

This study investigates the mechanism through which betulinic acid induces apoptosis in human prostate cancer cells. It reveals that betulinic acid activates both the p53 and NF-κB signaling pathways, leading to cell death. The research emphasizes the interplay between these pathways in regulating apoptosis and suggests that betulinic acid may

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June 26, 2025 No Comments

Estrogen Replacement Therapy Induces Antioxidant and Longevity-Related Genes in Women after Medically Induced Menopause

This 2021 clinical study investigated the effects of estrogen replacement therapy (ERT) on antioxidant and longevity-related gene expression in 16 women aged 18–42 undergoing medically induced menopause as part of fertility treatment. Blood samples were collected at four stages: baseline, post-menopause induction, after estrogen therapy, and after combined estrogen-progesterone therapy.

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June 26, 2025 No Comments

Targeting Autophagy in Cancer: Recent Advances and Future Directions

This 2019 review outlines the complex role of autophagy in cancer, acting as both a tumor suppressor and a survival mechanism for established malignancies. It examines the latest research on autophagy inhibition as a therapeutic strategy, especially in cancers with mutations in KRAS and p53, which rely on autophagy for

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June 26, 2025 No Comments

α-Lipoic acid prevents senescence, cell cycle arrest, and inflammatory cues in fibroblasts by inhibiting oxidative stress

This 2019 in vitro study published in Pharmacological Research (DOI: 10.1016/j.phrs.2019.01.003, PMID: 30611855) investigated the protective effects of alpha-lipoic acid (ALA) on fibroblast cells exposed to oxidative stress. The results demonstrated that ALA effectively reduced oxidative stress, inhibited DNA damage, and prevented cellular senescence by modulating key redox-sensitive pathways. Specifically,

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June 26, 2025 No Comments