Well Referenced

Tag: P21

Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner

This 2013 study explores the antiproliferative effects of resveratrol on gastric cancer cells through a Sirt1-dependent pathway. Resveratrol treatment caused significant G1 phase arrest and cellular senescence without inducing apoptosis. Mechanistically, it downregulated cyclin D1, CDK4, and CDK6 while upregulating p21 and p16, halting cell cycle progression. In vivo experiments

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June 26, 2025 No Comments

Inhibitory Effect of Zinc on Human Prostatic Carcinoma Cell Growth

This 1999 study examined the effects of zinc on the growth of human prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-independent). Exposure to physiological concentrations of zinc (100–1,000 ng/ml) resulted in significant growth inhibition in both cell lines, with LNCaP cells exhibiting greater sensitivity (IC50 ~100 ng/ml) compared to

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June 26, 2025 No Comments

Estrogen Replacement Therapy Induces Antioxidant and Longevity-Related Genes in Women after Medically Induced Menopause

This 2021 clinical study investigated the effects of estrogen replacement therapy (ERT) on antioxidant and longevity-related gene expression in 16 women aged 18–42 undergoing medically induced menopause as part of fertility treatment. Blood samples were collected at four stages: baseline, post-menopause induction, after estrogen therapy, and after combined estrogen-progesterone therapy.

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June 26, 2025 No Comments