Well Referenced

Tag: p16

Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner

This 2013 study explores the antiproliferative effects of resveratrol on gastric cancer cells through a Sirt1-dependent pathway. Resveratrol treatment caused significant G1 phase arrest and cellular senescence without inducing apoptosis. Mechanistically, it downregulated cyclin D1, CDK4, and CDK6 while upregulating p21 and p16, halting cell cycle progression. In vivo experiments

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June 26, 2025 No Comments

Outcomes of transoral laser microsurgery for oropharyngeal squamous cell carcinoma in Ireland and review of the literature on transoral approaches

This 2019 retrospective study assessed the outcomes of transoral laser microsurgery (TLM) in 26 patients with oropharyngeal squamous cell carcinoma (OPSCC) treated at South Infirmary Victoria University Hospital, Cork, Ireland, between 2010 and 2016. The cohort had a mean age of 56 years, with primary tumors located in the tonsil

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June 26, 2025 No Comments