Well Referenced

Tag: OXPHOS

Assessment of mitochondrial respiratory chain enzymes in cells and tissues

This review outlines standardized methodologies for assessing mitochondrial respiratory chain enzyme activity, highlighting their diagnostic utility for mitochondrial diseases. By offering consistent protocols and detailing enzymatic assays, the article supports their integration into both clinical and research settings. This enables precise identification of oxidative phosphorylation deficits, improving diagnostic accuracy and

Read More »
June 26, 2025 No Comments

Mitochondrial Dysfunction as an Underlying Cause of Skeletal Muscle Disorders

This systematic review discusses how mitochondrial dysfunction is a primary contributor to skeletal muscle disorders, driven by impaired oxidative phosphorylation, mtDNA mutations, calcium imbalance, defective mitophagy, and abnormalities in mitochondrial dynamics. These disruptions lead to decreased energy production, muscle degeneration, and cellular stress. The review emphasizes the need for targeted

Read More »
June 26, 2025 No Comments