Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss
The study titled “Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss” explores the impact of pregnenolone (Preg) on osteoclast differentiation and bone resorption. The research demonstrated that Preg inhibits RANKL-induced osteoclast differentiation and bone resorption by downregulating specific osteoclast marker genes and suppressing
June 26, 2025
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