Tag: organ dysfunction

International Consensus Criteria for Pediatric Sepsis and Septic Shock

This 2024 guideline, developed by the Society of Critical Care Medicine’s Pediatric Sepsis Definition Task Force, introduces the Phoenix Sepsis Score to define pediatric sepsis and septic shock. Sepsis is identified by a score of ≥2, indicating life-threatening dysfunction in respiratory, cardiovascular, coagulation, or neurological systems in children under 18

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Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups

This observational study examined how genetic polymorphisms impact dietary choline requirements and their prevalence across different ethnic and racial groups. Researchers analyzed 200 SNPs in 10 choline metabolism-related genes among 79 individuals on a low-choline diet. The study found that specific SNPs, such as PEMT rs12325817, increased the risk of

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