Well Referenced

Tag: orchiectomy

Effective testosterone suppression for prostate cancer: is there a best castration therapy?

This 2009 review examines the effectiveness of various castration methods for androgen deprivation therapy (ADT) in prostate cancer management, with a focus on achieving consistent suppression of testosterone to castrate levels. It compares surgical orchiectomy with pharmacological approaches, including luteinizing hormone-releasing hormone (LHRH) agonists and antagonists, and nonsteroidal antiandrogens. While

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June 26, 2025 No Comments

First-line treatment of metastatic prostate cancer. Androgen suppression for symptomatic disease

A review published in Prescrire International (2013) evaluated first-line treatments for metastatic prostate cancer, focusing on androgen suppression therapies like orchiectomy and gonadorelin agonists, which provide significant pain relief for about 80% of patients with bone metastases. However, the effect of these therapies on overall survival remains uncertain. Nonsteroidal antiandrogen

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June 26, 2025 No Comments

Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer

This systematic review evaluated the effectiveness and cost-effectiveness of various androgen suppression therapies for advanced prostate cancer, comparing monotherapy options such as orchiectomy, luteinizing hormone-releasing hormone (LHRH) agonists, and antiandrogens to combined androgen blockade (CAB), while also examining the timing of therapy initiation (immediate vs. deferred). The study found that

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June 26, 2025 No Comments