his randomized controlled trial examined the effects of combining testosterone replacement therapy (TRT) with intensive lifestyle intervention (ILI) in older men with obesity and hypogonadism. Over 12 months, TRT + ILI led to greater reductions in fat mass (6.1 kg vs. 1.9 kg; P < 0.001) and waist circumference (9.4
A randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism examined the effects of testosterone therapy on sexual function in older men with low testosterone levels. The study included 470 men aged 65 and older with testosterone levels below 275 ng/dL and symptoms of sexual dysfunction, physical
This editorial, published in the New England Journal of Medicine in 2023, discusses the safety considerations of testosterone replacement therapy (TRT) in older men. While it does not present new study data, it highlights the need for careful evaluation of TRT’s benefits and potential risks in aging males. The article
A 2004 randomized controlled trial published in the Journal of Gerontology: Biological Sciences and Medical Sciences (PMID: 14718489) examined the effects of testosterone replacement on behavior, depression, and cognitive function in older men with mild cognitive impairment. Over 12 weeks, 11 men aged 73-87 with low bioavailable testosterone levels received
The study titled Efficacy and Safety of Testosterone Treatment in Men: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians (PMID: 31905375) is a meta-analysis published in Annals of Internal Medicine in 2020. It evaluated the effects of testosterone therapy in men with low testosterone
This 2004 randomized controlled trial investigated the effects of testosterone therapy, with or without finasteride, on bone mineral density (BMD) in older men with low serum testosterone levels. The study found that testosterone administration significantly increased BMD, suggesting that testosterone therapy may be beneficial for improving bone health and reducing
