This 2015 survey-based study analyzed the prescribing practices of obesity medicine specialists prior to the 2012 approval of new anti-obesity medications. Among the 25% of 1,992 surveyed specialists who responded, many reported using stimulant medications like phentermine at higher doses and for longer durations than recommended. Off-label use of medications
This 2011 systematic review and meta-analysis evaluated the efficacy of metformin in mitigating weight gain induced by atypical antipsychotics in non-diabetic patients. Analyzing seven randomized, placebo-controlled trials encompassing 398 participants (five studies in adults and two in children), the study found that metformin significantly reduced body weight compared to placebo.
This case report describes the use of low-dose naltrexone (LDN) in a patient with systemic sclerosis experiencing severe pruritus unresponsive to conventional treatments. Administration of LDN at 4.5 mg nightly resulted in significant improvement in pruritus intensity and sleep quality within two weeks, with sustained benefits over several months. The
This 2009 study investigated the cytolytic effects of Lipostabil®, a phosphatidylcholine-based compound used in injection lipolysis, on various human cell types. In vitro experiments demonstrated that Lipostabil® induces rapid cell death in adipocytes, preadipocytes, vascular smooth muscle cells, skeletal myotubes, and renal epithelial cells. The cytolysis was not attributed to
