Well Referenced

Tag: Obstetrics

Assessing the Neuroprotective Benefits for Babies of Antenatal Magnesium Sulphate: An Individual Participant Data Meta-Analysis

This comprehensive individual participant data meta-analysis, encompassing five randomized controlled trials with 5,493 women and 6,131 infants, evaluated the efficacy of antenatal magnesium sulphate (MgSO₄) in reducing the risk of cerebral palsy (CP) and death in preterm births. The analysis revealed that MgSO₄ administration significantly decreased the incidence of CP

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June 26, 2025 No Comments

NAD Deficiency, Congenital Malformations, and Niacin Supplementation

In this pivotal 2017 study published in the New England Journal of Medicine, Shi et al. investigate the link between NAD+ deficiency and congenital malformations. Through genomic sequencing of families with multiple congenital anomalies, the researchers identified loss-of-function mutations in the HAAO and KYNU genes, which are integral to the

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June 26, 2025 No Comments

Pyridoxine for Nausea and Vomiting of Pregnancy: A Randomized, Double-Blind, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled trial, published in the American Journal of Obstetrics and Gynecology in September 1995, evaluated the efficacy of pyridoxine (vitamin B6) in treating nausea and vomiting during pregnancy. Conducted at Chiang Mai University in Thailand, the study enrolled 59 pregnant women experiencing nausea and vomiting before 17

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June 26, 2025 No Comments