Well Referenced

Tag: Obesity Medicine

A meta-analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time-restricted eating for weight loss

This 2023 meta-analysis by Elortegui Pascual et al. evaluated the comparative effectiveness of three intermittent fasting (IF) regimens—alternate day fasting (ADF), the 5:2 diet, and time-restricted eating (TRE)—on weight loss, compared to traditional caloric energy restriction (CER). The study analyzed 24 randomized controlled trials encompassing 1,768 participants. Results indicated that

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June 26, 2025 No Comments

A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II)

This 2013 randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy and safety of naltrexone sustained-release (SR)/bupropion SR combination therapy in overweight and obese adults. A total of 1,496 participants with a BMI of 27–45 kg/m² and at least one comorbidity were randomized to receive either the combination therapy or

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June 26, 2025 No Comments

A study of abrupt phentermine cessation in patients in a weight management program

This 2011 study by Hendricks and Greenway evaluated the potential for abuse, dependence, and withdrawal symptoms in patients who abruptly discontinued long-term phentermine therapy for obesity. Thirty-five patients who independently stopped taking phentermine were assessed using a modified 18-item Kampman Cocaine Selective Severity Assessment scale tailored for phentermine. Their results

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June 26, 2025 No Comments

A two-year randomized trial of obesity treatment in primary care practice

This 2011 randomized controlled trial by Wadden et al. evaluated the effectiveness of three obesity treatment strategies in primary care settings over two years. The study involved 390 obese adults (mean BMI ~38) randomized into three groups: usual care (quarterly visits with primary care providers), brief lifestyle counseling (quarterly visits

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June 26, 2025 No Comments

Answers to Clinical Questions in the Primary Care Management of People with Obesity: Pharmacologic Management

This clinical review addresses common questions primary care providers face regarding pharmacologic management of obesity. It emphasizes that pharmacotherapy should be considered for adults with a BMI ≥30 kg/m² or ≥27 kg/m² with comorbidities, in conjunction with lifestyle interventions. The article reviews FDA-approved medications available at the time, including orlistat,

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June 26, 2025 No Comments