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Tag: NRF2 activation

The glutathione system: a new drug target in neuroimmune disorders

This 2014 review discusses the glutathione (GSH) system as a critical regulator of redox homeostasis, immune function, and mitochondrial integrity in neuroimmune disorders. GSH depletion is associated with increased oxidative and nitrosative stress, which can impair neural and immune functions, contributing to diseases such as depression, chronic fatigue syndrome, and

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June 26, 2025 No Comments

Nebulized Glutathione as a Key Antioxidant for the Treatment of Oxidative Stress in Neurodegenerative Conditions

Nebulized glutathione (GSH), a powerful intracellular antioxidant, shows promise as a novel therapy for combating oxidative stress in neurodegenerative conditions such as Parkinson’s and Alzheimer’s disease. Acting through its sulfhydryl group, GSH neutralizes reactive oxygen and nitrogen species, supports mitochondrial function, regulates apoptosis and autophagy, and activates the NRF2 antioxidant

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June 26, 2025 No Comments