This 2019 review highlights the central role of NAD⁺ in neuronal health, emphasizing its involvement in energy metabolism, DNA repair, mitochondrial function, and stress responses. The authors discuss how declining NAD⁺ levels with age contribute to neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and ALS. NAD⁺-dependent enzymes, including sirtuins and
This 2016 review elucidates the synergistic relationship between NAD⁺ and sirtuins in regulating aging and longevity. It details how NAD⁺-dependent sirtuins, particularly SIRT1 and SIRT3, influence metabolic pathways, mitochondrial function, and stress responses. The paper discusses how declining NAD⁺ levels with age impair sirtuin activity, leading to disrupted nuclear-mitochondrial communication
This comprehensive review examines the pivotal role of NAD⁺ in cardiac physiology, aging, and disease. It details how NAD⁺ levels decline with age, obesity, and hypertension, contributing to cardiovascular diseases. The article discusses mechanisms of NAD⁺ metabolism in cardiomyocytes, including biosynthesis and degradation pathways, and the impact on mitochondrial function
