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Tag: norepinephrine

Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings

This in vitro and animal study explored the role of magnesium in regulating blood pressure by examining its effect on norepinephrine release from sympathetic nerve endings. Using hypertensive and normotensive rat models, as well as cultured PC12 cells, researchers found that magnesium significantly inhibited norepinephrine release—reducing it by 51% in

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June 26, 2025 No Comments

Residual effects of short-term whole-body cold-water immersion on the cytokine profile, white blood cell count, and blood markers of stress

This study examined the physiological and immune responses to short-term cold-water immersion (CWI) in healthy young males. The immersion at 14°C for 10 minutes led to a stress response, with increased heart rate, muscle shivering, and elevated levels of epinephrine, norepinephrine, and cortisol. Cytokine analysis showed a delayed increase in

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June 26, 2025 No Comments

Role of monoamine oxidase, nitric oxide synthase and regional brain monoamines in the antidepressant-like effects of methylene blue and selected structural analogues

This animal study evaluated the antidepressant-like effects of methylene blue (MB) and its analogues, methylene green (MG) and others, demonstrating significant reductions in depressive behaviors in rodents. MB and MG showed dose-dependent improvements in depression symptoms, primarily by enhancing mitochondrial function, inhibiting monoamine oxidase (MAO) and nitric oxide synthase (NOS),

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June 26, 2025 No Comments

Methylene blue and its analogues as antidepressant compounds

This review explores the antidepressant and anxiolytic properties of methylene blue (MB) and its analogues. MB exerts its effects through mechanisms such as monoamine oxidase A (MAO-A) inhibition, which increases neurotransmitter levels, and modulation of nitric oxide pathways. These actions suggest MB’s potential as a therapeutic agent for treating mood

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June 26, 2025 No Comments