Well Referenced

Tag: non-invasive assessment

Transient elastography (FibroScan®) with controlled attenuation parameter in the assessment of liver steatosis and fibrosis in patients with nonalcoholic fatty liver disease – Where do we stand?

This 2016 review evaluates the utility of transient elastography (TE) with controlled attenuation parameter (CAP) in assessing liver steatosis and fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. TE with CAP is a non-invasive, rapid, and reproducible method that quantifies liver stiffness and steatosis levels, offering an alternative to liver

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June 26, 2025 No Comments

Biomarkers for assessment of intestinal permeability in clinical practice

This 2021 observational study published in American Journal of Physiology-Gastrointestinal and Liver Physiology (PMID: 34009040) evaluated the correlation between the traditional lactulose/mannitol (L/M) test for intestinal permeability and surrogate biomarkers such as plasma lipopolysaccharide-binding protein (LBP) and fecal zonulin. In two cohorts—51 healthy individuals and 27 with obesity—the study found

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June 26, 2025 No Comments

Development and Validation of Test for “Leaky Gut” Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults

This 2021 randomized controlled trial published in Gastroenterology (PMID: 33865841) evaluated the accuracy and reproducibility of sugar probe testing to assess intestinal permeability in healthy adults and IBS-D patients. Researchers found that ^13C-mannitol, unlike ^12C-mannitol, served as a reliable marker for small intestinal permeability, with consistent results unaffected by age,

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June 26, 2025 No Comments