Tag: non-genomic actions

This review explores the metabolic effects of 3,5-diiodo-L-thyronine (3,5-T2), an endogenous thyroid hormone metabolite. In rodent models, exogenous 3,5-T2 administration rapidly increases resting metabolic rate and induces beneficial hypolipidemic effects. The mechanisms are primarily non-genomic, targeting mitochondria to enhance oxidative phosphorylation and fatty acid oxidation. While some thyroid hormone receptor-mediated