Well Referenced

Tag: non-alcoholic fatty liver disease

Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease

This 2022 review article examines the role of branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—in metabolic health and disease. Elevated BCAA levels are linked to insulin resistance, type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). BCAAs activate the mTORC1 pathway, influencing cell growth and glucose metabolism.

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June 26, 2025 No Comments

Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells

This 2012 study investigated the effects of alpha-lipoic acid (ALA) on lipid metabolism in HepG2 cells, a human liver cell line. The researchers found that ALA treatment activated the AMP-activated protein kinase (AMPK) signaling pathway, leading to increased expression of adipose triglyceride lipase (ATGL). This upregulation of ATGL enhanced lipid

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June 26, 2025 No Comments

The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study

This randomized, double-blind, placebo-controlled trial beautifully demonstrated the powerful benefits of grape seed extract (GSE) supplementation in improving several key metabolic and liver health parameters in individuals with non-alcoholic fatty liver disease (NAFLD). Over the course of two months, participants who took 520 mg of GSE daily experienced impressively significant

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June 26, 2025 No Comments

Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease

This study investigates the effects of betaine supplementation on oxidative stress, inflammation, apoptosis, autophagy, and the Akt/mTOR signaling pathway in a mouse model of methionine-choline deficiency (MCD)-induced non-alcoholic fatty liver disease (NAFLD). Betaine supplementation significantly reduced liver transaminases, hepatosteatosis, inflammatory cytokines (TNF-α, IL-6), oxidative stress, and apoptosis while enhancing antioxidant

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June 26, 2025 No Comments