Well Referenced

Tag: NLRP3 inflammasome

Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations

This 2021 review article explores the potential of methylene blue (MB) as a therapeutic agent for COVID-19, focusing on its mechanisms of action and clinical investigations. MB exhibits multiple antiviral and immunomodulatory properties: it can inhibit SARS-CoV-2 replication by interfering with the viral spike protein’s binding to ACE2 receptors, disrupt

Read More »
June 26, 2025 No Comments

NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia

This 2022 in vivo animal study published in Biochemical and Biophysical Research Communications (DOI: 10.1016/j.bbrc.2022.02.092) examined the role of the NLRP3 inflammasome in cognitive decline during endotoxemia. Using a mouse model, researchers found that LPS-induced systemic inflammation elevated IL-1β levels in the cerebrospinal fluid, triggered microglial NLRP3 inflammasome activation, and

Read More »
June 26, 2025 No Comments

Raising the Alarm: Environmental Factors in the Onset and Maintenance of Chronic (Low-Grade) Inflammation in the Gastrointestinal Tract

This 2022 review published in Digestive Diseases and Sciences (PMID: 34981314) explores how environmental factors, such as food additives and contaminants (including pesticides and microplastics), contribute to chronic low-grade inflammation in the gastrointestinal (GI) tract. These factors disrupt gut microbiota, compromise the intestinal barrier, and promote systemic inflammation, leading to

Read More »
June 26, 2025 No Comments

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

This review article discusses the role of the NLRP3 inflammasome in aging, focusing on its activation and contribution to “inflammaging” — a state of chronic low-grade inflammation associated with age-related diseases like cancer, cardiovascular disease, and neurodegenerative disorders. The NLRP3 inflammasome, activated by signals such as mitochondrial dysfunction and lysosomal

Read More »
June 26, 2025 No Comments

Drivers of age-related inflammation and strategies for healthspan extension

This review discusses the role of chronic inflammation driven by the NLRP3 inflammasome in age-related conditions such as arthritis, diabetes, cardiovascular disease, and Alzheimer’s disease. It highlights how the accumulation of damage-associated molecular patterns (DAMPs) with age activates NLRP3, increasing IL-1β and IL-18 production and contributing to systemic inflammation. The

Read More »
June 26, 2025 No Comments