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Tag: nitrosative stress

Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)

This 2015 review by Islam et al. examines the detrimental effects of peroxynitrite-induced DNA damage and the subsequent activation of poly(ADP-ribose) polymerase (PARP) in various human diseases. Peroxynitrite, formed by the reaction of nitric oxide with superoxide radicals, can cause DNA strand breaks, leading to the overactivation of PARP. This

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June 26, 2025 No Comments

Glutathione in cancer biology and therapy

The article “Glutathione in Cancer Biology and Therapy” examines the multifaceted role of glutathione (GSH) in cancer, emphasizing its impact on cell growth, DNA synthesis, mutagenic processes, and resistance to chemotherapy and radiation. Elevated levels of GSH in many tumors contribute to drug resistance and survival during oxidative and nitrosative

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June 26, 2025 No Comments