This 2021 preclinical study evaluated the impact of intraperitoneal ozone therapy on erectile function and nitric oxide synthase (NOS) expression in streptozotocin-induced diabetic rats. Eighteen rats were divided into control, diabetes mellitus (DM), and DM + ozone therapy groups. After two weeks of ozone treatment, the DM + ozone group
This 2013 study investigated the effects of chronic rapamycin treatment in transgenic mice exhibiting Alzheimer’s-like symptoms. Administered after symptom onset, rapamycin significantly restored cerebral blood flow, increased vascular density, reduced amyloid plaque accumulation, and minimized microhemorrhages. These effects were mediated by activation of endothelial nitric oxide synthase (eNOS), enhancing nitric
This review explores the potential benefits of L-arginine supplementation in mitigating age-related vascular endothelial dysfunction. L-arginine plays a crucial role in nitrogen detoxification, immune function, growth hormone secretion, and insulin regulation. It serves as a substrate for nitric oxide synthase, promoting nitric oxide (NO) production, which enhances vasodilation and vascular
This review explores the antidepressant and anxiolytic properties of methylene blue (MB) and its analogues. MB exerts its effects through mechanisms such as monoamine oxidase A (MAO-A) inhibition, which increases neurotransmitter levels, and modulation of nitric oxide pathways. These actions suggest MB’s potential as a therapeutic agent for treating mood
