Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line
This in vitro study investigated the effects of quercetin on human mast cells (HMC-1) stimulated to produce inflammatory cytokines. The researchers found that quercetin significantly inhibited the expression and production of TNF-α, IL-1β, IL-6, and IL-8 by attenuating the activation of NF-kappaB and p38 MAPK pathways—two major regulators of inflammation.
June 26, 2025
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