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Tag: NF-κB pathway

Lipopolysaccharides (LPSs) as Potent Neurotoxic Glycolipids in Alzheimer’s Disease (AD)

This 2022 review published in the International Journal of Molecular Sciences (DOI: 10.3390/ijms232012671) explores how lipopolysaccharides (LPSs) from Gram-negative gut bacteria contribute to the pathogenesis of Alzheimer’s disease (AD). The article details how LPSs can translocate into systemic circulation through compromised gut and blood-brain barriers—especially in aging or those with

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June 26, 2025 No Comments

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice

This 2019 in vivo study published in Scientific Reports (DOI: 10.1038/s41598-019-42286-8) explored the effects of lipopolysaccharide (LPS)-induced neuroinflammation on cognition in mice. LPS administration activated microglia, increased pro-inflammatory cytokines (TNF-α, IL-1β), decreased anti-inflammatory cytokines (IL-4, IL-10), and impaired memory performance in behavioral tests. It also triggered NF-κB pathway activation and

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June 26, 2025 No Comments