Well Referenced

Tag: NF-κB inhibition

From French Paradox to cancer treatment: anti-cancer activities and mechanisms of resveratrol

This comprehensive review explores the anti-cancer properties of resveratrol, a polyphenolic compound found in grapes and red wine. Resveratrol exerts its effects through multiple mechanisms, including induction of apoptosis via p53 activation, inhibition of NF-κB signaling, modulation of the PI3K/Akt pathway, and suppression of angiogenesis through VEGF downregulation. It also

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June 26, 2025 No Comments

Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy

The study “Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy,” published in Nature Medicine (2003), investigated benfotiamine, a lipid-soluble form of thiamine (vitamin B1), and its ability to prevent diabetic retinopathy by simultaneously inhibiting three harmful metabolic pathways activated by high blood sugar—the hexosamine, DAG-PKC,

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June 26, 2025 No Comments