Well Referenced

Tag: neuropathy

Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

This article discusses the pleiotropic effects of alpha-lipoic acid (ALA) and its potential therapeutic applications in diabetes and other chronic diseases. The study highlights ALA’s role as an antioxidant, improving insulin sensitivity, reducing inflammation, and combating oxidative stress. Additionally, ALA has shown promise in managing complications of diabetes, such as

Read More »
June 26, 2025 No Comments

Therapeutic potential of benfotiamine and its molecular targets

This review article explores the therapeutic potential of benfotiamine, a lipid-soluble derivative of thiamine (vitamin B1), highlighting its superior bioavailability and its ability to activate transketolase—an enzyme that diverts harmful glycolytic intermediates from pathways that lead to advanced glycation end products (AGEs), a key factor in diabetic vascular complications. Benfotiamine

Read More »
June 26, 2025 No Comments

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

The study titled “Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies” (Antioxidants (Basel), 2020, PMID: 33086555) assessed the safety of α-lipoic acid (ALA) supplementation by analyzing data from 71 randomized placebo-controlled trials involving 4,749 participants (2,558 receiving ALA and 2,294 on placebo).

Read More »
June 26, 2025 No Comments