Well Referenced

Tag: Neurological Disorders

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

This 2014 review outlines the therapeutic potential and mechanisms of N-acetylcysteine (NAC) in treating various neurological disorders. As a precursor to glutathione, NAC plays a critical role in reducing oxidative stress and modulating inflammation. It influences glutamatergic neurotransmission, restores redox balance, and promotes neuronal survival. The review highlights preclinical and

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June 26, 2025 No Comments

Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

This systematic review explores the role of functional food nutrients, such as flavonoids (curcumin, resveratrol), probiotics, vitamin D, and omega-3 fatty acids, in enhancing brain health by modulating oxidative stress and neuroinflammation through the Nrf2 antioxidant pathway. These nutrients activate protective genes like HO-1 and Sirt1, helping to maintain neurosteroid

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June 26, 2025 No Comments

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

This review discusses zonulin, a protein that regulates tight junctions and modulates the permeability of both the intestinal and blood-brain barriers. It highlights how dysregulation of zonulin, triggered by microbial components, may contribute to neurological and gastrointestinal disorders. The review also explores potential therapeutic interventions targeting the zonulin pathway, particularly

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June 26, 2025 No Comments

Chronic inflammation in the etiology of disease across the life span

This systematic review discusses the role of chronic inflammation in the etiology of age-related diseases, including cardiovascular, neurological, and metabolic disorders. It explores how inflammation accelerates aging and contributes to the development of various chronic diseases by activating immune pathways and releasing pro-inflammatory cytokines. The study highlights interventions targeting these

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June 26, 2025 No Comments

Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer’s disease

This article explores the potential therapeutic applications of methylene blue (MB) in treating neurodegenerative conditions like traumatic brain injury, brain ischemia, and Alzheimer’s disease. MB demonstrates multiple beneficial effects, including anti-apoptotic and anti-inflammatory actions, inhibition of protein aggregation, activation of autophagy, and modulation of mitochondrial function. These properties suggest that

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June 26, 2025 No Comments

Treatment of Symptomatic Diabetic Polyneuropathy With the Antioxidant Alpha-Lipoic Acid: A Meta-Analysis

The meta-analysis titled “Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis” (Diabet Med, 2004, PMID: 14984445) evaluated the efficacy and safety of intravenous alpha-lipoic acid (600 mg/day) over three weeks in diabetic patients with symptomatic polyneuropathy. Analyzing data from four randomized, double-masked, placebo-controlled trials (n=1,258), the

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June 26, 2025 No Comments