This 2010 evidence-based review by the Medical Advisory Secretariat assesses the clinical utility and cost-effectiveness of neuroimaging (CT, MRI) in evaluating chronic headaches. The analysis indicates that routine neuroimaging in patients with chronic headaches without neurological abnormalities or “red flags” is of low diagnostic yield and may not be cost-effective.
This neuroimaging study assessed how obesity impacts brain structure across the adult lifespan using MRI data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort. Analyzing 527 individuals aged 20–87, researchers found that overweight and obese adults—especially those in midlife—had significantly reduced white matter volume compared to their lean
This 2020 review provides a comprehensive overview of evolving strategies in the management of brain metastases (BMs), the most common intracranial tumors in adults, affecting 20–40% of patients with metastatic cancer. Advances in neuroimaging facilitate earlier and more accurate detection. Management has shifted from traditional whole-brain radiotherapy (WBRT) and neurosurgical
This study explored the effects of acute methylene blue (MB) administration on cerebral blood flow (CBF) and metabolism in healthy humans and rats. Contrary to expectations that MB would enhance cerebral metabolism, intravenous administration (0.5–1 mg/kg in humans; 2–4 mg/kg in rats) led to significant, dose-dependent reductions in global CBF
