necrosis Archives - Well Referenced

Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling

This study investigates the effects of ascorbic acid (vitamin C) on human laryngeal squamous cell carcinoma (LSCC) cells, showing that it induces necrosis through the activation of reactive oxygen species (ROS), protein kinase C (PKC), and calcium signaling pathways. The findings suggest that ascorbic acid may serve as a potential

June 26, 2025 No Comments

The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons

This in vitro study explored the cytotoxic effects of malondialdehyde (MDA), a product of lipid peroxidation, on cortical neurons and the protective role of carnosine. MDA exposure led to decreased neuronal viability, triggering both apoptosis and necrosis, mediated by reactive oxygen species (ROS) generation, mitochondrial dysfunction, and activation of JNK

June 26, 2025 No Comments

Tag: necrosis

Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling

The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons