Compounds that Extend Longevity Are Protective in Neurodegenerative Diseases and Provide a Novel Treatment Strategy for These Devastating Disorders
This 2020 review examines the therapeutic potential of longevity-extending compounds—metformin, rapamycin, resveratrol, N-acetyl-L-cysteine (NAC), and curcumin—in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and ALS. These compounds modulate aging-related cellular pathways that contribute to neurodegeneration, including mitochondrial dysfunction, oxidative stress, protein aggregation, and chronic inflammation. Each agent demonstrates neuroprotective effects
June 26, 2025
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