This 2013 retrospective cohort study by Mansi et al. investigated the association between statin use and musculoskeletal conditions in a military population. Using propensity score matching, 6,967 statin users were compared with 6,967 non-users. Results showed that statin users had significantly higher odds of being diagnosed with musculoskeletal diseases (OR
This randomized controlled trial compared ultrasound-guided ozone injections to corticosteroid injections in the treatment of shoulder impingement syndrome. The study involved 30 patients and found that both treatments significantly improved pain and disability scores, but corticosteroid injections provided quicker symptom relief, with better outcomes at 2 weeks and 2 months
This systematic review and meta-analysis compared the effectiveness of ozone injections with corticosteroid injections for reducing musculoskeletal pain. The analysis, which included 534 participants, found that corticosteroids were significantly more effective in reducing pain in the short term (SMD=0.31, p=0.04). Despite this, ozone injections showed promise as an alternative treatment,
This article reviews the efficacy of ozone therapy in treating acute and chronic pain, particularly in musculoskeletal and joint disorders. Ozone therapy demonstrates significant benefits in reducing pain, inflammation, and promoting tissue healing by enhancing oxygen delivery and stimulating antioxidant defenses. The review indicates that ozone therapy can provide notable
This study evaluates the efficacy of intramuscular oxygen-ozone therapy for treating low back pain (LBP) using paravertebral ozone injections. A total of 109 patients were treated, with 67 completing the study. Results showed that 79% of patients experienced a significant reduction in pain (VAS reduction by 2.3 points) and improvement
This critical review explores the clinical use of medical ozone therapy for managing musculoskeletal pain, such as low back pain, knee osteoarthritis, and disc herniation. It evaluates the efficacy, safety, and quality control of ozone procedures and devices across multiple clinical trials. The findings suggest that ozone therapy can significantly
This systematic review published in Biomolecules (2021) analyzes the safety, mechanisms of action, and efficacy of oxygen-ozone (O₂O₃) therapy in patients with musculoskeletal disorders, particularly low back pain and knee osteoarthritis. The therapy works by inducing moderate oxidative stress, which produces signaling molecules that modulate inflammation and oxidative stress pathways,
