The 2014 article titled “Glutamine and intestinal barrier function” (PMID: 24965526) reviews the vital role of glutamine in maintaining intestinal barrier integrity. Glutamine is shown to promote enterocyte proliferation, regulate the expression and assembly of tight junction proteins, and support overall mucosal health. These functions are particularly critical under stress
The 2017 review article “Glutamine and the Regulation of Intestinal Permeability: From Bench to Bedside” (PMID: 27749689) highlights glutamine’s essential role in preserving and regulating intestinal barrier function. The review outlines how glutamine supports enterocyte proliferation, modulates tight junction protein expression, and protects mucosal integrity. It draws on both animal
This review explores the role of phosphatidylcholine (PC) in maintaining colonic mucosal integrity and its therapeutic potential for ulcerative colitis (UC). PC forms a hydrophobic barrier in the intestines, preventing bacterial invasion and inflammation, but in UC patients, there is a significant reduction in mucus PC content, making them more
