This 2017 study assessed the combined effects of sirolimus (an mTOR inhibitor) and metformin (an AMPK activator) on colon cancer cell lines (HT29, SW620, HCT116) and in a mouse model. The combination treatment (Met/S) significantly inhibited cell viability and tumor growth more than either agent alone. Mechanistically, the combination downregulated
This 2022 study evaluates the repurposing of clindamycin (CLD), a macrolide antibiotic, as a novel therapeutic agent for drug-resistant glioblastoma (GBM). CLD was shown to inhibit tumor cell growth by targeting the mTORC1 signaling pathway, reducing phosphorylation of downstream targets p70S6K and S6. Importantly, CLD also suppressed MGMT expression, a
This 2019 comprehensive review discusses heterotopic ossification (HO), the pathological formation of bone in soft tissues. HO is often triggered by trauma, surgery, burns, or neurological injuries. The review covers clinical features, radiographic and histopathologic diagnosis, and treatment options, including NSAIDs, radiation therapy, and surgical excision. It also explores the
This study examined the antidepressant-like effects of cannabidiol (CBD) in rodent models, demonstrating that a single dose (7-30 mg/kg) produced rapid and sustained reductions in depressive-like behaviors. The effects were associated with increased expression of synaptic proteins (synaptophysin and PSD95), elevated brain-derived neurotrophic factor (BDNF) levels, and enhanced spine density
