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Tag: MTHFR C677T polymorphism

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

This review explores the MTHFR C677T polymorphism, a genetic variation that affects folate metabolism and leads to elevated homocysteine levels, which are associated with an increased risk of cardiovascular diseases, neurological disorders, diabetes, and other health conditions. The article discusses the need for genetic testing and the use of folic

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June 26, 2025 No Comments

Quantification of multi-pathway metabolites related to folate metabolism and application in natural population with MTHFR C677T polymorphism

This study analyzed the impact of the MTHFR C677T polymorphism on folate metabolism and its effects on health. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), the study identified changes in folate-related metabolites in individuals with this genetic variant, particularly in 5-methyltetrahydrofolate levels and metabolites involved in DNA synthesis. The findings highlight

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June 26, 2025 No Comments