Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCγ-IP3R related Ca2+ fluctuations
This study explored quercetin’s effects on pseudo-allergic reactions, particularly those mediated by the Mrgprx2 receptor in mast cells. In vivo, quercetin reduced Evans blue leakage and paw swelling, indicating suppressed allergic responses. In vitro, it inhibited calcium influx and mast cell degranulation by disrupting the PLCγ-IP3R signaling pathway. Molecular docking
June 26, 2025
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