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Tag: MOTS-c

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

This 2021 study published in Nature Communications investigated the role of MOTS-c, a mitochondrial-derived peptide, in regulating age-related physical decline and muscle homeostasis. The researchers found that MOTS-c levels significantly increased in human skeletal muscle and plasma following exercise. In mouse models, both young and aged mice treated with MOTS-c

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June 26, 2025 No Comments

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

This 2016 study introduces MOTS-c, a mitochondrial-derived peptide encoded within the 12S rRNA gene, highlighting its role in regulating metabolic homeostasis. MOTS-c enhances insulin sensitivity, promotes glucose utilization, and prevents high-fat diet-induced obesity and insulin resistance in mice. It primarily targets skeletal muscle but also influences adipose tissue, acting through

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June 26, 2025 No Comments