This 2015 review challenges conventional views on obesity and weight loss by highlighting the “obesity paradox,” where obese individuals with cardiovascular disease (CVD) or type 2 diabetes (T2D) may have better survival rates than their normal-weight counterparts. The authors argue that weight loss does not universally lead to health improvements
This population-based cohort study utilized data from 14,289 adults in NHANES III (1988–1994) with mortality follow-up through 2011 to evaluate the relationship between low blood lead levels and long-term mortality. The analysis revealed that individuals with blood lead levels between 1.0 and 6.7 μg/dL faced significantly higher risks of all-cause
This 2018 cohort study introduced “Phenotypic Age,” a composite biomarker derived from chronological age and nine clinical chemistry markers, to estimate biological aging and associated mortality risk. Utilizing data from NHANES IV (1999–2010), the study analyzed 11,432 adults aged 20–84 and 185 adults aged 85 and older. Findings revealed that
This 2022 review article explores various biomarkers and methodologies for assessing biological age, emphasizing the concept of aging clocks. It discusses the development and application of different types of aging clocks, including epigenetic clocks based on DNA methylation patterns, glycomic clocks analyzing glycan structures, and telomeric clocks measuring telomere length.
This systematic review analyzed 23 prospective cohort studies to identify blood-borne biomarkers predictive of mortality risk in adults aged 50–75 years. Out of 51 biomarkers examined, 20 were significantly associated with mortality. Notably, elevated levels of C-reactive protein (CRP) were linked to increased all-cause, cancer, and cardiovascular mortality. Similarly, higher
This 2015 study by Schöttker et al. investigates the association between oxidative stress biomarkers and all-cause mortality in older adults. In a German cohort of 2,932 participants with a median age of 70, researchers measured derivatives of reactive oxygen metabolites (d-ROMs) and total thiol levels (TTL) as proxies for oxidative
This 2015 meta-analysis conducted by the CHANCES consortium analyzed data from over 10,000 individuals aged 45–85 across four European cohorts to test the free radical/oxidative stress theory of aging. The study assessed oxidative stress using two biomarkers: derivatives of reactive oxygen metabolites (D-ROMs) as an indicator of oxidative burden and
This cohort study published in the American Journal of Cardiology examines the association between elevated C-reactive protein (CRP) levels and the risk of cardiovascular events and mortality in patients with various cardiovascular conditions such as coronary artery disease, peripheral artery disease, and cerebrovascular disease. The study found that higher CRP
This study explored the link between serum malondialdehyde (MDA) levels and 30-day mortality in patients with severe malignant middle cerebral artery infarction (MMCAI). Elevated MDA levels were significantly higher in MMCAI patients compared to healthy controls and were associated with increased mortality risk. An MDA level above 2.27 nmol/mL predicted
