Well Referenced

Tag: mood

β-Glucan supplementation, allergy symptoms, and quality of life in self-described ragweed allergy sufferers

This 2013 randomized, double-blind, placebo-controlled study assessed the effects of daily supplementation with 250 mg of Wellmune WGP® β-1,3/1,6-glucan over four weeks in 48 adults with self-described moderate ragweed allergies. Compared to placebo, β-glucan supplementation significantly reduced total allergy symptoms by 28%, symptom severity by 52%, and Visual Analog Scale

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June 26, 2025 No Comments

A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study

This 6-month double-blind, randomized, placebo-controlled pilot trial assessed the effects of chromium picolinate supplementation on binge eating disorder (BED) in 24 overweight adults. Participants were randomized to receive either 1000 mcg/day (high dose), 600 mcg/day (moderate dose), or placebo. The moderate dose group exhibited significant reductions in fasting glucose levels

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June 26, 2025 No Comments

Lessons From the Testosterone Trial

This 2018 review by Snyder et al. summarizes findings from the Testosterone Trials (TTrials), a coordinated set of seven placebo-controlled, double-blind trials involving 788 men aged 65 and older with low testosterone levels. The trials assessed the effects of testosterone therapy on various health domains. Key findings include: increased sexual

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June 26, 2025 No Comments

High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial

This 2002 randomized, double-blind, placebo-controlled trial assessed the effects of 3,000 mg/day sustained-release ascorbic acid (vitamin C) on sexual behavior and mood in 81 healthy young adults over 14 days. Participants recorded daily instances of penile-vaginal intercourse (PVI), noncoital partner sex, and masturbation, and completed the Beck Depression Inventory pre-

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June 26, 2025 No Comments

Dehydroepiandrosterone therapy as female androgen replacement

The article titled “Dehydroepiandrosterone therapy as female androgen replacement” (Seminars in Reproductive Medicine, 2006, PMID: 16633983) reviews the role of dehydroepiandrosterone (DHEA) supplementation as androgen replacement therapy in women, particularly focusing on menopausal and postmenopausal populations. It highlights potential improvements in sexual function, bone mineral density, mood, and overall well-being,

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June 26, 2025 No Comments

Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis

The article analyzes the effects of DHEA therapy in postmenopausal women with normal adrenal function. It finds that DHEA may improve sexual function and mood but has no significant impact on bone density. The study also highlights the risks, including acne and facial hair, and emphasizes the need for further

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June 26, 2025 No Comments

Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women

This study, published in Gynecological Endocrinology in 2003 (PMID: 12724021), examined the effects of various hormone replacement therapy (HRT) regimens on neurosteroid levels in 186 postmenopausal women over 12 months. Results showed that all HRT preparations significantly increased allopregnanolone levels, a neurosteroid with sedative and anxiolytic properties, suggesting a potential

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June 26, 2025 No Comments